Synthesis, Characterisation and Mechanism of Action of Anticancer 3-Fluoroazetidin-2-ones

• Ngā kaituhi matua: Azizah M. Malebari (Author), Gabriela Duffy Morales (Author), Brendan Twamley (Author), Darren Fayne (Author), Mohemmed Faraz Khan (Author), Eavan C. McLoughlin (Author), Niamh M. O'Boyle (Author), Daniela M. Zisterer (Author), Mary J. Meegan (Author)
• Hōputu: Pukapuka
• I whakaputaina: MDPI AG, 2022-08-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

The stilbene combretastatin A-4 (CA-4) is a potent microtubule-disrupting agent interacting at the colchicine-binding site of tubulin. In the present work, the synthesis, characterisation and mechanism of action of a series of 3-fluoro and 3,3-difluoro substituted β-lactams as analogues of the tubul...