Synthesis, Characterisation and Mechanism of Action of Anticancer 3-Fluoroazetidin-2-ones

• Main Authors: Azizah M. Malebari (Author), Gabriela Duffy Morales (Author), Brendan Twamley (Author), Darren Fayne (Author), Mohemmed Faraz Khan (Author), Eavan C. McLoughlin (Author), Niamh M. O'Boyle (Author), Daniela M. Zisterer (Author), Mary J. Meegan (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The stilbene combretastatin A-4 (CA-4) is a potent microtubule-disrupting agent interacting at the colchicine-binding site of tubulin. In the present work, the synthesis, characterisation and mechanism of action of a series of 3-fluoro and 3,3-difluoro substituted β-lactams as analogues of the tubul...