FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes

• Main Authors: Mark Z. Chen (Author), Joshua C. Chang (Author), Jose Zavala-Solorio (Author), Lance Kates (Author), Minh Thai (Author), Annie Ogasawara (Author), Xiaobo Bai (Author), Sean Flanagan (Author), Victor Nunez (Author), Khanhky Phamluong (Author), James Ziai (Author), Robert Newman (Author), Søren Warming (Author), Ganesh Kolumam (Author), Junichiro Sonoda (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Fibroblast Growth Factor 21 (FGF21) is a potent stimulator of brown fat thermogenesis that improves insulin sensitivity, ameliorates hepatosteatosis, and induces weight loss by engaging the receptor complex comprised of Fibroblast Growth Factor Receptor 1 (FGFR1) and the requisite corecep...