PLA₂-Triggered Activation of Cyclosporine-Phospholipid Prodrug as a Drug Targeting Approach in Inflammatory Bowel Disease Therapy

• Main Authors: Milica Markovic (Author), Shimon Ben-Shabat (Author), Jagadeesh Nagendra Manda (Author), Karina Abramov-Harpaz (Author), Clil Regev (Author), Yifat Miller (Author), Aaron Aponick (Author), Ellen M. Zimmermann (Author), Arik Dahan (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oral medication with activity specifically at the inflamed sites throughout the gastrointestinal tract and limited systemic exposure would be a major advance in our therapeutic approach to inflammatory bowel disease (IBD). For this purpose, we have designed a prodrug by linking active drug moiety to...