Oncoproteins E6 and E7 upregulate topoisomerase I to activate the cGAS-PD-L1 pathway in cervical cancer development

• Main Authors: Ying Luo (Author), Mengda Niu (Author), Yanfei Liu (Author), Miaochang Zhang (Author), Yuanyuan Deng (Author), Dan Mu (Author), Junfen Xu (Author), Shiyuan Hong (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Fag: article
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Background: Cervical cancer (CC) stands as a significant health threat to women globally, with high-risk human papillomaviruses as major etiologic agents. The DNA damage repair (DDR) protein topoisomerase I (TOP1) has been linked to various cancers, yet its distinct roles and mechanisms in CC are no...