Effects of a Novel Thiadiazole Derivative with High Anticancer Activity on Cancer Cell Immunogenic Markers: Mismatch Repair System, PD-L1 Expression, and Tumor Mutation Burden

• Main Authors: Sofia Sagredou (Author), Panagiotis Dalezis (Author), Eirini Papadopoulou (Author), Maria Voura (Author), Maria V. Deligiorgi (Author), Michail Nikolaou (Author), Mihalis I. Panayiotidis (Author), George Nasioulas (Author), Vasiliki Sarli (Author), Dimitrios T. Trafalis (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Microsatellite instability (MSI), tumor mutation burden (TMB), and programmed cell death ligand-1 (PD-L1) are particularly known as immunotherapy predictive biomarkers. MSI and TMB are closely related to DNA mismatch repair (MMR) pathway functionality, while the PD-L1 checkpoint mediates cancer cell...