Ocular pharmacological and biochemical profiles of 6-thioguanine: a drug repurposing study

• Main Authors: Maria Consiglia Trotta (Author), Carlo Gesualdo (Author), Caterina Claudia Lepre (Author), Marina Russo (Author), Franca Ferraraccio (Author), Iacopo Panarese (Author), Ernesto Marano (Author), Paolo Grieco (Author), Francesco Petrillo (Author), Anca Hermenean (Author), Francesca Simonelli (Author), Michele D'Amico (Author), Claudio Bucolo (Author), Francesca Lazzara (Author), Filomena De Nigris (Author), Settimio Rossi (Author), Chiara Bianca Maria Platania (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction:The purine analog 6-thioguanine (6TG), an old drug approved in the 60s to treat acute myeloid leukemia (AML), was tested in the diabetic retinopathy (DR) experimental in vivo setting along with a molecular modeling approach.Methods:A computational analysis was performed to investigate t...