Dimethyl fumarate inhibits necroptosis and alleviates systemic inflammatory response syndrome by blocking the RIPK1-RIPK3-MLKL axis

• Main Authors: Fu-li Shi (Author), Li-sha Yuan (Author), Tak-sui Wong (Author), Qing Li (Author), Ya-ping Li (Author), Rong Xu (Author), Yi-ping You (Author), Tao Yuan (Author), Hong-rui zhang (Author), Zi-jian Shi (Author), Qing-bing Zha (Author), Bo Hu (Author), Xian-hui He (Author), Dong-yun Ouyang (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Necroptosis has been implicated in various inflammatory diseases including tumor-necrosis factor-α (TNF-α)-induced systemic inflammatory response syndrome (SIRS). Dimethyl fumarate (DMF), a first-line drug for treating relapsing-remitting multiple sclerosis (RRMS), has been shown to be effective aga...