Systematic Development of Self-Nanoemulsifying Liquisolid Tablets to Improve the Dissolution and Oral Bioavailability of an Oily Drug, Vitamin K1

• Main Authors: Yongtao Tong (Author), Yuli Wang (Author), Meiyan Yang (Author), Jiahui Yang (Author), Lu Chen (Author), Xiaoyang Chu (Author), Chunhong Gao (Author), Qian Jin (Author), Wei Gong (Author), Chunsheng Gao (Author)
• Format: Book
• Published: MDPI AG, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study is to improve the dissolution and oral bioavailability of an oily drug, vitamin K1 (VK1) by combination of self-nanoemulsifying and liquisolid technologies. The optimal liquid self-nanoemulsifying drug delivery systems (SNEDDS) formulation including VK1 (oil), mixture of so...