Concentrations of Co-Administered Meropenem and Vancomycin in Spinal Tissues Relevant for the Treatment of Pyogenic Spondylodiscitis-An Experimental Microdialysis Study

• Main Authors: Josefine Slater (Author), Maiken Stilling (Author), Pelle Hanberg (Author), Sofus Vittrup (Author), Martin Bruun Knudsen (Author), Sara Kousgaard Tøstesen (Author), Josephine Olsen Kipp (Author), Mats Bue (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Co-administration of meropenem and vancomycin has been suggested as a systemic empirical antibiotic treatment of pyogenic spondylodiscitis. The aim of this study was, in an experimental porcine model, to evaluate the percentage of an 8-h dosing interval of co-administered meropenem and vancomycin co...