Physiologically Relevant In Vitro-In Vivo Correlation (IVIVC) Approach for Sildenafil with Site-Dependent Dissolution

• Egile Nagusiak: Tae Hwan Kim (Egilea), Soyoung Shin (Egilea), Seok Won Jeong (Egilea), Jong Bong Lee (Egilea), Beom Soo Shin (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2019-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

This study aimed to establish a physiologically relevant in vitro-in vivo correlation (IVIVC) model reflecting site-dependent dissolution kinetics for sildenafil based on population-pharmacokinetic (POP-PK) modeling. An immediate release (IR, 20 mg) and three sustained release (SR, 60 mg) sildenafil...