ACT001 improved cardiovascular function in septic mice by inhibiting the production of proinflammatory cytokines and the expression of JAK-STAT signaling pathway

• Main Authors: Zhen Peng (Author), Xiaolong Lv (Author), Xintong Wang (Author), Ting Shang (Author), Jing Chang (Author), Khalid Salahdiin (Author), Yue Guo (Author), Zhisen Zhang (Author), Ru Shen (Author), Ming Lyu (Author), Shuang He (Author), Jian Yang (Author), Yuefei Wang (Author), Xiumei Gao (Author), Yan Zhu (Author), Yuxin Feng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sepsis is a life-threatening multiple organ dysfunction syndrome (MODS) caused by a microbial infection that leads to high morbidity and mortality worldwide. Sepsis-induced cardiomyopathy (SIC) and coagulopathy promote the progression of adverse outcomes in sepsis. Here, we reported that ACT001, a m...