HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease.

• Main Authors: María G Alvarez (Author), Miriam Postan (Author), D Brent Weatherly (Author), María C Albareda (Author), John Sidney (Author), Alessandro Sette (Author), Carina Olivera (Author), Alejandro H Armenti (Author), Rick L Tarleton (Author), Susana A Laucella (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Previously, we identified a set of HLA-A020.1-restricted trans-sialidase peptides as targets of CD8+ T cell responses in HLA-A0201+ individuals chronically infected by T. cruzi. METHODS AND FINDINGS:Herein, we report the identification of peptides encoded by the same trans-sialidase gene...