HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease.

• Prif Awduron: María G Alvarez (Awdur), Miriam Postan (Awdur), D Brent Weatherly (Awdur), María C Albareda (Awdur), John Sidney (Awdur), Alessandro Sette (Awdur), Carina Olivera (Awdur), Alejandro H Armenti (Awdur), Rick L Tarleton (Awdur), Susana A Laucella (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Public Library of Science (PLoS), 2008-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

BACKGROUND:Previously, we identified a set of HLA-A020.1-restricted trans-sialidase peptides as targets of CD8+ T cell responses in HLA-A0201+ individuals chronically infected by T. cruzi. METHODS AND FINDINGS:Herein, we report the identification of peptides encoded by the same trans-sialidase gene...