HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease.

• Egile Nagusiak: María G Alvarez (Egilea), Miriam Postan (Egilea), D Brent Weatherly (Egilea), María C Albareda (Egilea), John Sidney (Egilea), Alessandro Sette (Egilea), Carina Olivera (Egilea), Alejandro H Armenti (Egilea), Rick L Tarleton (Egilea), Susana A Laucella (Egilea)
• Formatua: Liburua
• Argitaratua: Public Library of Science (PLoS), 2008-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

BACKGROUND:Previously, we identified a set of HLA-A020.1-restricted trans-sialidase peptides as targets of CD8+ T cell responses in HLA-A0201+ individuals chronically infected by T. cruzi. METHODS AND FINDINGS:Herein, we report the identification of peptides encoded by the same trans-sialidase gene...