HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease.

• Auteurs principaux: María G Alvarez (Auteur), Miriam Postan (Auteur), D Brent Weatherly (Auteur), María C Albareda (Auteur), John Sidney (Auteur), Alessandro Sette (Auteur), Carina Olivera (Auteur), Alejandro H Armenti (Auteur), Rick L Tarleton (Auteur), Susana A Laucella (Auteur)
• Format: Livre
• Publié: Public Library of Science (PLoS), 2008-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

BACKGROUND:Previously, we identified a set of HLA-A020.1-restricted trans-sialidase peptides as targets of CD8+ T cell responses in HLA-A0201+ individuals chronically infected by T. cruzi. METHODS AND FINDINGS:Herein, we report the identification of peptides encoded by the same trans-sialidase gene...