HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease.

• Príomhchruthaitheoirí: María G Alvarez (Údar), Miriam Postan (Údar), D Brent Weatherly (Údar), María C Albareda (Údar), John Sidney (Údar), Alessandro Sette (Údar), Carina Olivera (Údar), Alejandro H Armenti (Údar), Rick L Tarleton (Údar), Susana A Laucella (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Public Library of Science (PLoS), 2008-01-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

BACKGROUND:Previously, we identified a set of HLA-A020.1-restricted trans-sialidase peptides as targets of CD8+ T cell responses in HLA-A0201+ individuals chronically infected by T. cruzi. METHODS AND FINDINGS:Herein, we report the identification of peptides encoded by the same trans-sialidase gene...