HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease.

• Автори: María G Alvarez (Автор), Miriam Postan (Автор), D Brent Weatherly (Автор), María C Albareda (Автор), John Sidney (Автор), Alessandro Sette (Автор), Carina Olivera (Автор), Alejandro H Armenti (Автор), Rick L Tarleton (Автор), Susana A Laucella (Автор)
• Формат: Книга
• Опубліковано: Public Library of Science (PLoS), 2008-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

BACKGROUND:Previously, we identified a set of HLA-A020.1-restricted trans-sialidase peptides as targets of CD8+ T cell responses in HLA-A0201+ individuals chronically infected by T. cruzi. METHODS AND FINDINGS:Herein, we report the identification of peptides encoded by the same trans-sialidase gene...