The importance of molecular biology in development, prognosis, treatment and resistance to targeted therapy in gastrointestinal stromal tumors

• Główni autorzy: Alessandro Comandone (Autor), Elisa Berno (Autor), Simona Chiadò Cutin (Autor), Antonella Boglione (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2011-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Gastrointestinal stromal tumors (GISTs) are the commonest mesenchymal tumors of the gastroenteric tract, and are generally believed to originate from the neoplastic transformation of the interstitial cells of Cajal, the pacemaker structures of the stomach and intestine. Exon and genetic mutations (p...