Patients' Pharmacogenetic Characteristics and the Risk of Adverse Reactions to Non-steroidal Anti-inflammatory Drugs: Case Reports

• Main Authors: A. S. Zhiryakova (Author), N. P. Denisenko (Author), A. V. Kryukov (Author), K. A. Akmalova (Author), S. N. Tuchkova (Author), K. B. Mirzaev (Author), D. A. Sychev (Author)
• Format: Book
• Published: Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products», 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

INTRODUCTION. The variability in patient response to non-steroidal anti-inflammatory drugs (NSAIDs) may be due to genetic polymorphisms. Decreased-function or non-functional CYP2C9 alleles are known to be significant contributors to response variability, and research is being conducted on the potent...