In Vivo Inhibition of CYP3A-Mediated Midazolam Metabolism by Anchusan in Rats

• Main Authors: Yusuke Saito (Author), Yuki Nishimura (Author), Norimitsu Kurata (Author), Mariko Iwase (Author), Kayo Aoki (Author), Hajime Yasuhara (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cytochrome P450 (CYP)-mediated drug interactions caused by Kampo medicine have not been investigated sufficiently. The current study was conducted to reveal the effect of anchusan, a commonly used Kampo formula for gastrointestinal disease, on CYP3A-mediated drug metabolism in rats. The pharmacokine...