Galactosylated hydroxyl‐polyamidoamine dendrimer targets hepatocytes and improves therapeutic outcomes in a severe model of acetaminophen poisoning‐induced liver failure

• Main Authors: Joshua E. Porterfield (Author), Rishi Sharma (Author), Ambar Scarlet Jimenez (Author), Nirnath Sah (Author), Sean McCracken (Author), Lucia Zhang (Author), Hyoung‐Tae An (Author), Seulki Lee (Author), Sujatha Kannan (Author), Anjali Sharma (Author), Rangaramanujam M. Kannan (Author)
• Format: Book
• Published: Wiley, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Toxicity to hepatocytes caused by various insults including drugs is a common cause of chronic liver failure requiring transplantation. Targeting therapeutics specifically to hepatocytes is often a challenge since they are relatively nonendocytosing unlike the highly phagocytic Kupffer cell...