Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related behaviours

• Main Authors: Eleftheria Pervolaraki (Author), Stephen P. Hall (Author), Denise Foresteire (Author), Takashi Saito (Author), Takaomi C. Saido (Author), Miles A. Whittington (Author), Colin Lever (Author), James Dachtler (Author)
• Format: Book
• Published: The Company of Biologists, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We studied a new amyloid-beta precursor protein (App) knock-in mouse model of Alzheimer's disease (AppNL-G-F), containing the Swedish KM670/671NL mutation, the Iberian I716F mutation and the Artic E693G mutation, which generates elevated levels of amyloid beta (Aβ)40 and Aβ42 without the confou...