Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice

• Main Authors: Yasushi Kuraishi (Author), Eiji Ohtsuka (Author), Tasuku Nakano (Author), Sanae Kawai (Author), Tsugunobu Andoh (Author), Hiroshi Nojima (Author), Kiyoshi Kamimura (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study investigated endogenous mediators involved in mosquito allergy-associated itching in mice. An intradermal injection of an extract of mosquito salivary gland elicited marked scratching in sensitized mice. The 5-lipoxygenase inhibitor zileuton (100 mg/kg), the 5-lipoxygenase activating pept...