Novel thienopyrimidine derivatives as dual EGFR and VEGFR-2 inhibitors: design, synthesis, anticancer activity and effect on cell cycle profile

• 主要な著者: Aml E.-S. Mghwary (著者), Ehab M. Gedawy (著者), Aliaa M. Kamal (著者), Suzan M. Abuel-Maaty (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Aim: Design and synthesis of thienopyrimidine derivatives as dual EGFR and VEGFR-2 inhibitors.Material and methods: A series of novel 6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidine derivatives with different substituents on C-4 position was synthesized and evaluated for their anticance...