Binding symmetry and surface flexibility mediate antibody self-association

• Main Authors: Joseph D. Schrag (Author), Marie-Ève Picard (Author), Francis Gaudreault (Author), Louis-Patrick Gagnon (Author), Jason Baardsnes (Author), Mahder S. Manenda (Author), Joey Sheff (Author), Christophe Deprez (Author), Cassio Baptista (Author), Hervé Hogues (Author), John F. Kelly (Author), Enrico O. Purisima (Author), Rong Shi (Author), Traian Sulea (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Solution stability is an important factor in the optimization of engineered biotherapeutic candidates such as monoclonal antibodies because of its possible effects on manufacturability, pharmacology, efficacy and safety. A detailed atomic understanding of the mechanisms governing self-association of...