Binding symmetry and surface flexibility mediate antibody self-association

• প্রধান লেখক: Joseph D. Schrag (লেখক), Marie-Ève Picard (লেখক), Francis Gaudreault (লেখক), Louis-Patrick Gagnon (লেখক), Jason Baardsnes (লেখক), Mahder S. Manenda (লেখক), Joey Sheff (লেখক), Christophe Deprez (লেখক), Cassio Baptista (লেখক), Hervé Hogues (লেখক), John F. Kelly (লেখক), Enrico O. Purisima (লেখক), Rong Shi (লেখক), Traian Sulea (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2019-10-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Solution stability is an important factor in the optimization of engineered biotherapeutic candidates such as monoclonal antibodies because of its possible effects on manufacturability, pharmacology, efficacy and safety. A detailed atomic understanding of the mechanisms governing self-association of...