Altered Blood-Brain Barrier Dynamics in the C9orf72 Hexanucleotide Repeat Expansion Mouse Model of Amyotrophic Lateral Sclerosis

• Main Authors: Yijun Pan (Author), Yoshiteru Kagawa (Author), Jiaqi Sun (Author), Bradley J. Turner (Author), Cheng Huang (Author), Anup D. Shah (Author), Ralf B. Schittenhelm (Author), Joseph A. Nicolazzo (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For peripherally administered drugs to reach the central nervous system (CNS) and treat amyotrophic lateral sclerosis (ALS), they must cross the blood-brain barrier (BBB). As mounting evidence suggests that the ultrastructure of the BBB is altered in individuals with ALS and in animal models of ALS...