Biochemical Discrimination of the Down Syndrome-Related Metabolic and Oxidative/Nitrosative Stress Alterations from the Physiologic Age-Related Changes through the Targeted Metabolomic Analysis of Serum

• Main Authors: Giacomo Lazzarino (Author), Angela M. Amorini (Author), Renata Mangione (Author), Miriam Wissam Saab (Author), Enrico Di Stasio (Author), Michelino Di Rosa (Author), Barbara Tavazzi (Author), Giuseppe Lazzarino (Author), Graziano Onder (Author), Angelo Carfì (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Down Syndrome (DS) is a neurodevelopmental disorder that is characterized by an accelerated aging process, frequently associated with the development of Alzheimer's disease (AD). Previous studies evidenced that DS patients have various metabolic anomalies, easily measurable in their serum sampl...