Toxic Responses Induced at High Doses May Affect Benchmark Doses

• Asıl Yazarlar: Jürg A. Zarn (Yazar), Ursina A. Zürcher (Yazar), H. Christoph Geiser (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: SAGE Publishing, 2020-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

To derive reference points (RPs) for health-based guidance values, the benchmark dose (BMD) approach increasingly replaces the no-observed-adverse-effect level approach. In the BMD approach, the RP corresponds to the benchmark dose lower confidence bounds (BMDLs) of a mathematical dose-response mode...