The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation

• Egile Nagusiak: Reiko Fumimoto (Egilea), Eiko Sakai (Egilea), Yu Yamaguchi (Egilea), Hiroshi Sakamoto (Egilea), Yutaka Fukuma (Egilea), Kazuhisa Nishishita (Egilea), Kuniaki Okamoto (Egilea), Takayuki Tsukuba (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2012-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Osteoclasts (OCLs) are multinucleated bone resorbing cells whose differentiation is regulated by receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor (M-CSF). It is known that inflammatory cytokines and oxidative stress stimulate differentiation of OCL...