The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation

• Main Authors: Reiko Fumimoto (Author), Eiko Sakai (Author), Yu Yamaguchi (Author), Hiroshi Sakamoto (Author), Yutaka Fukuma (Author), Kazuhisa Nishishita (Author), Kuniaki Okamoto (Author), Takayuki Tsukuba (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoclasts (OCLs) are multinucleated bone resorbing cells whose differentiation is regulated by receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor (M-CSF). It is known that inflammatory cytokines and oxidative stress stimulate differentiation of OCL...