New spiro-indeno[1,2-b]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for halting non-small cell lung cancer; stereoselective synthesis, molecular dynamics and structural insights

• Main Authors: Assem Barakat (Author), Saeed Alshahrani (Author), Abdullah Mohammed Al-Majid (Author), Abdullah Saleh Alamary (Author), Matti Haukka (Author), Marwa M. Abu-Serie (Author), Luis R. Domingo (Author), Sajda Ashraf (Author), Zaheer Ul-Haq (Author), Mohamed S. Nafie (Author), Mohamed Teleb (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite the crucial role of CDK2 in tumorigenesis, few inhibitors reached clinical trials for managing lung cancer, the leading cause of cancer death. Herein, we report combinatorial stereoselective synthesis of rationally designed spiroindeno[1,2-b]quinoxaline-based CDK2 inhibitors for NSCLC therap...