Quantitative systems pharmacology model of GITR‐mediated T cell dynamics in tumor microenvironment

• Autori principali: Yan Ji (Autore), Kumpal Madrasi (Autore), Deborah A. Knee (Autore), Lore Gruenbaum (Autore), Joshua F. Apgar (Autore), John M. Burke (Autore), Bruce Gomes (Autore)
• Natura: Libro
• Pubblicazione: Wiley, 2023-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract T cell interaction in the tumor microenvironment is a key component of immuno‐oncology therapy. Glucocorticoid‐induced tumor necrosis factor receptor (TNFR)‐related protein (GITR) is expressed on immune cells including regulatory T cells (Tregs) and effector T cells (Teffs). Preclinical dat...