Quantitative systems pharmacology model of GITR‐mediated T cell dynamics in tumor microenvironment

• Main Authors: Yan Ji (Author), Kumpal Madrasi (Author), Deborah A. Knee (Author), Lore Gruenbaum (Author), Joshua F. Apgar (Author), John M. Burke (Author), Bruce Gomes (Author)
• Format: Book
• Published: Wiley, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract T cell interaction in the tumor microenvironment is a key component of immuno‐oncology therapy. Glucocorticoid‐induced tumor necrosis factor receptor (TNFR)‐related protein (GITR) is expressed on immune cells including regulatory T cells (Tregs) and effector T cells (Teffs). Preclinical dat...