Bacterial carbonic anhydrases as drug targets: towards novel antibiotics ?
Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes which catalyze the hydration of carbon dioxide to bicarbonate and protons. Many pathogenic bacteria encode such enzymes belonging to the a-, b-, and/or g-CA families. In the last decade, the a-CAs from Neisseria spp. and Helicobacter pylori as...
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Frontiers Media S.A.,
2011-07-01T00:00:00Z.
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