Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells

• Main Authors: Yueshan Sun (Author), Xueqin Jiang (Author), Rong Pan (Author), Xiaogang Zhou (Author), Dalian Qin (Author), Rui Xiong (Author), Yiling Wang (Author), Wenqiao Qiu (Author), Anguo Wu (Author), Jianming Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pathogenesis of Huntington's disease (HD), an inherited progressive neurodegenerative disease, is highly associated with the cytotoxicity-inducing mutant huntingtin (mHtt) protein. Emerging evidence indicates that autophagy plays a pivotal role in degrading aggregated proteins such as mHtt...