KATP channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca2+]c rise and an indirect inhibition mediated by somatostatin

• Egile Nagusiak: Bilal Singh (Egilea), Firas Khattab (Egilea), Heeyoung Chae (Egilea), Lieven Desmet (Egilea), Pedro L. Herrera (Egilea), Patrick Gilon (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2021-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Objective: Glucagon is secreted by pancreatic α-cells in response to hypoglycemia and its hyperglycemic effect helps to restore normal blood glucose. Insulin and somatostatin (SST) secretions from β- and δ-cells, respectively, are stimulated by glucose by mechanisms involving an inhibition of their...