Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity

• Asıl Yazarlar: Shiraz S. Fidai (Yazar), Aarti E. Sharma (Yazar), Daniel N. Johnson (Yazar), Jeremy P. Segal (Yazar), Ricardo R. Lastra (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: University of São Paulo, 2018-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

5-Fluorouracil (5-FU), in combination with other cytotoxic drugs, is commonly used to treat a variety of cancers. Dihydropyrimidine dehydrogenase (DPD) catalyzes the first catabolic step of the 5-FU degradation pathway, converting 80% of 5-FU to its inactive metabolite. Approximately 0.3% of the pop...