Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity

• Main Authors: Shiraz S. Fidai (Author), Aarti E. Sharma (Author), Daniel N. Johnson (Author), Jeremy P. Segal (Author), Ricardo R. Lastra (Author)
• Format: Book
• Published: University of São Paulo, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

5-Fluorouracil (5-FU), in combination with other cytotoxic drugs, is commonly used to treat a variety of cancers. Dihydropyrimidine dehydrogenase (DPD) catalyzes the first catabolic step of the 5-FU degradation pathway, converting 80% of 5-FU to its inactive metabolite. Approximately 0.3% of the pop...