The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance

• Main Authors: Maija Toppila (Author), Maria Hytti (Author), Eveliina Korhonen (Author), Sofia Ranta-aho (Author), Niina Harju (Author), Markus M. Forsberg (Author), Kai Kaarniranta (Author), Aaro Jalkanen (Author), Anu Kauppinen (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Increased oxidative stress, dysfunctional cellular clearance, and chronic inflammation are associated with age-related macular degeneration (AMD). Prolyl oligopeptidase (PREP) is a serine protease that has numerous cellular functions, including the regulation of oxidative stress, protein aggregation...