Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H2O2-Dependent Manner

• Main Authors: Collin D. Heer (Author), Andrew B. Davis (Author), David B. Riffe (Author), Brett A. Wagner (Author), Kelly C. Falls (Author), Bryan G. Allen (Author), Garry R. Buettner (Author), Robert A. Beardsley (Author), Dennis P. Riley (Author), Douglas R. Spitz (Author)
• Format: Book
• Published: MDPI AG, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lung cancer, together with head and neck cancer, accounts for more than one-fourth of cancer deaths worldwide. New, non-toxic therapeutic approaches are needed. High-dose IV vitamin C (aka, pharmacological ascorbate; P-AscH−) represents a promising adjuvant to radiochemotherapy that exerts its anti-...