Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor

• Main Authors: Alvaro Yogi (Author), Greg Hussack (Author), Henk van Faassen (Author), Arsalan S. Haqqani (Author), Christie E. Delaney (Author), Eric Brunette (Author), Jagdeep K. Sandhu (Author), Melissa Hewitt (Author), Traian Sulea (Author), Kristin Kemmerich (Author), Danica B. Stanimirovic (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The ability of drugs and therapeutic antibodies to reach central nervous system (CNS) targets is greatly diminished by the blood-brain barrier (BBB). Receptor-mediated transcytosis (RMT), which is responsible for the transport of natural protein ligands across the BBB, was identified as a way to inc...