A simple HPLC-MS/MS method for the determination of polymyxin B in human plasma and its application in the pharmacokinetic study in elderly patients infected with multidrug-resistant Gram-negative bacteria

• Asıl Yazarlar: Sheng Hu (Yazar), Nan Guo (Yazar), Juan Zeng (Yazar), Yue Li (Yazar), Yahui Zhang (Yazar), Jinjiao Jiang (Yazar), Bing Leng (Yazar), Chengwu Shen (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Introduction: Polymyxin B is widely used to treat infections caused by multidrug-resistant Gram-negative bacteria. However, the pharmacokinetic study data of PB in the elderly are scarce. Herein, a simple method to measure the concentration of PB in human plasma was developed and validated by high p...