Synthesis and Evaluations of Novel Apocynin Derivatives as Anti-Glioma Agents

• Main Authors: Tao Yang (Author), Da-Wei Zang (Author), Wei Shan (Author), An-Chen Guo (Author), Jian-Ping Wu (Author), Yong-Jun Wang (Author), Qun Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Apocynin (4-hydroxy-3-methoxyacetophenone) is a natural polyphenolic compound with multiple biological activities. In the present study, a series of apocynin derivatives were designed and synthesized. The in silico ADMET prediction, blood-brain barrier (BBB) penetration assay, anti-NADPH oxidase act...