A model of DENV-3 infection that recapitulates severe disease and highlights the importance of IFN-γ in host resistance to infection.

• المؤلفون الرئيسيون: Vivian V Costa (مؤلف), Caio T Fagundes (مؤلف), Deborah F Valadão (مؤلف), Daniel Cisalpino (مؤلف), Ana Carolina F Dias (مؤلف), Kátia D Silveira (مؤلف), Lucas M Kangussu (مؤلف), Thiago V Ávila (مؤلف), Maria Rosa Q Bonfim (مؤلف), Daniela Bonaventura (مؤلف), Tarcília A Silva (مؤلف), Lirlândia P Sousa (مؤلف), Milene A Rachid (مؤلف), Leda Q Vieira (مؤلف), Gustavo B Menezes (مؤلف), Ana Maria de Paula (مؤلف), Alena Atrasheuskaya (مؤلف), George Ignatyev (مؤلف), Mauro M Teixeira (مؤلف), Danielle G Souza (مؤلف)
• التنسيق: كتاب
• منشور في: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

There are few animal models of dengue infection, especially in immunocompetent mice. Here, we describe alterations found in adult immunocompetent mice inoculated with an adapted Dengue virus (DENV-3) strain. Infection of mice with the adapted DENV-3 caused inoculum-dependent lethality that was prece...