A model of DENV-3 infection that recapitulates severe disease and highlights the importance of IFN-γ in host resistance to infection.

• Main Authors: Vivian V Costa (Author), Caio T Fagundes (Author), Deborah F Valadão (Author), Daniel Cisalpino (Author), Ana Carolina F Dias (Author), Kátia D Silveira (Author), Lucas M Kangussu (Author), Thiago V Ávila (Author), Maria Rosa Q Bonfim (Author), Daniela Bonaventura (Author), Tarcília A Silva (Author), Lirlândia P Sousa (Author), Milene A Rachid (Author), Leda Q Vieira (Author), Gustavo B Menezes (Author), Ana Maria de Paula (Author), Alena Atrasheuskaya (Author), George Ignatyev (Author), Mauro M Teixeira (Author), Danielle G Souza (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There are few animal models of dengue infection, especially in immunocompetent mice. Here, we describe alterations found in adult immunocompetent mice inoculated with an adapted Dengue virus (DENV-3) strain. Infection of mice with the adapted DENV-3 caused inoculum-dependent lethality that was prece...