Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction.

• Main Authors: Rosane M B Teles (Author), Jing Lu (Author), Maria Tió-Coma (Author), Isabela M B Goulart (Author), Sayera Banu (Author), Deanna Hagge (Author), Kidist Bobosha (Author), Tom H M Ottenhoff (Author), Matteo Pellegrini (Author), Annemieke Geluk (Author), Robert L Modlin (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reversal reactions (RRs) in leprosy are characterized by a reduction in the number of bacilli in lesions associated with an increase in cell-mediated immunity against the intracellular bacterium Mycobacterium leprae, the causative pathogen of leprosy. To identify the mechanisms that contribute to ce...