pH-Sensitive Chitosan-Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells

pH-Sensitive Chitosan-Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells

Chitosan has been extensively studied as a genetic drug delivery platform. However, its efficiency is limited by the strength of DNA and RNA binding. Expecting a reduced binding strength of cargo with chitosan, we proposed including heparin as a competing polyanion in the polyplexes. We developed ch...

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Main Authors: Iuliia Pilipenko (Author), Viktor Korzhikov-Vlakh (Author), Vladimir Sharoyko (Author), Nan Zhang (Author), Monika Schäfer-Korting (Author), Eckart Rühl (Author), Christian Zoschke (Author), Tatiana Tennikova (Author)
Format: Book
Published: MDPI AG, 2019-07-01T00:00:00Z.
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