pH-Sensitive Chitosan-Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells

• Κύριοι συγγραφείς: Iuliia Pilipenko (Συγγραφέας), Viktor Korzhikov-Vlakh (Συγγραφέας), Vladimir Sharoyko (Συγγραφέας), Nan Zhang (Συγγραφέας), Monika Schäfer-Korting (Συγγραφέας), Eckart Rühl (Συγγραφέας), Christian Zoschke (Συγγραφέας), Tatiana Tennikova (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2019-07-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Chitosan has been extensively studied as a genetic drug delivery platform. However, its efficiency is limited by the strength of DNA and RNA binding. Expecting a reduced binding strength of cargo with chitosan, we proposed including heparin as a competing polyanion in the polyplexes. We developed ch...