Effects of Antiepileptic Drugs on Spontaneous Recurrent Seizures in a Novel Model of Extended Hippocampal Kindling in Mice

• Main Authors: Hongmei Song (Author), Uilki Tufa (Author), Jonathan Chow (Author), Nila Sivanenthiran (Author), Chloe Cheng (Author), Stellar Lim (Author), Chiping Wu (Author), Jiachun Feng (Author), James H. Eubanks (Author), Liang Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epilepsy is a common neurological disorder characterized by naturally-occurring spontaneous recurrent seizures and comorbidities. Kindling has long been used to model epileptogenic mechanisms and to assess antiepileptic drugs. In particular, extended kindling can induce spontaneous recurrent seizure...