1,8-Cineole ameliorates right ventricle dysfunction associated with pulmonary arterial hypertension by restoring connexin43 and mitochondrial homeostasis

• Main Authors: Jorge M. Alves-Silva (Author), Mónica Zuzarte (Author), Carla Marques (Author), Sofia Viana (Author), Inês Preguiça (Author), Rui Baptista (Author), Cátia Ferreira (Author), Carlos Cavaleiro (Author), Neuza Domingues (Author), Vilma A. Sardão (Author), Paulo J. Oliveira (Author), Flávio Reis (Author), Lígia Salgueiro (Author), Henrique Girão (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For the first time, the present study unravels a cardiospecific therapeutic approach for Pulmonary Arterial Hypertension (PAH), a disease with a very poor prognosis and high mortality rates due to right ventricle (RV) dysfunction. We first established a new in vitro model of high-pressure-induced hy...