ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Adenosine Receptor Activation by ATP Through Rapid and Localized Generation of Adenosine by Ecto-nucleotidases

• Main Authors: Isao Matsuoka (Author), Satoko Ohkubo (Author)
• Formato: Libro
• Publicado: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Extracellular ATP is now recognized as a neurotransmitter or neuromodilator in the nervous system, producing diverse physiological effects by activating multiple P2 receptors. Although P2-receptor signaling is terminated by hydrolysis of ATP by the ecto-nucleotidase cascade, such a metabolic step le...