Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone

The cytochrome P450 2D6 (<i>CYP2D6</i>) genotype is the single most important determinant of CYP2D6 activity as well as interindividual and interpopulation variability in CYP2D6 activity. Here, the CYP2D6 activity score provides an established tool to categorize the large number of CYP2D...

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Main Authors: Simeon Rüdesheim (Author), Dominik Selzer (Author), Thomas Mürdter (Author), Svitlana Igel (Author), Reinhold Kerb (Author), Matthias Schwab (Author), Thorsten Lehr (Author)
Format: Book
Published: MDPI AG, 2022-08-01T00:00:00Z.
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