Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance

• Main Authors: Sheila R. Costford (Author), Bram Brouwers (Author), Meghan E. Hopf (Author), Lauren M. Sparks (Author), Mauro Dispagna (Author), Ana P. Gomes (Author), Heather H. Cornnell (Author), Chris Petucci (Author), Peter Phelan (Author), Hui Xie (Author), Fanchao Yi (Author), Glenn A. Walter (Author), Timothy F. Osborne (Author), David A. Sinclair (Author), Randall L. Mynatt (Author), Julio E. Ayala (Author), Stephen J. Gardell (Author), Steven R. Smith (Author)
• Format: Book
• Published: Elsevier, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD+), an essential co-substrate regulating a myriad of signaling pathways. We produced a mouse that overexpressed NAMPT in skeletal muscle (...