Internalization of Foldamer-Based DNA Mimics through a Site-Specific Antibody Conjugate to Target HER2-Positive Cancer Cells

• Main Authors: Valentina Corvaglia (Author), Imène Ait Mohamed Amar (Author), Véronique Garambois (Author), Stéphanie Letast (Author), Aurélie Garcin (Author), Céline Gongora (Author), Maguy Del Rio (Author), Caroline Denevault-Sabourin (Author), Nicolas Joubert (Author), Ivan Huc (Author), Philippe Pourquier (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibition of protein-DNA interactions represents an attractive strategy to modulate essential cellular functions. We reported the synthesis of unique oligoamide-based foldamers that adopt single helical conformations and mimic the negatively charged phosphate moieties of B-DNA. These mimics alter t...