Development of a Dynamic Physiologically Based Mechanistic Kidney Model to Predict Renal Clearance

• Huvudskapare: Weize Huang (Författare, medförfattare), Nina Isoherranen (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: Wiley, 2018-09-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.

Renal clearance is usually predicted via empirical approaches including quantitative structure activity relationship and allometric scaling. Recently, mechanistic prediction approaches using in silico kidney models have been proposed. However, empirical scaling factors are typically used to adjust f...